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Ahmed T. Alahmar

Ahmed T. Alahmar

University of Manchester, UK

Title: Skin expression of advanced glycation end products (AGEs), RAGE and Glyoxalase-I in patients with 40 years of diabetes


Biography: Ahmed T. Alahmar



To assess skin distribution and expression of AGEs, RAGE and GLO-I in patients with 40 years of diabetes mellitus and to correlate these expressions with measures of small and large nerve fibre damage.


Sixty-seven patients with type 1 diabetes mellitus of short (<15 years, n=20), intermediate  (15-40 years, n=25) and long (>40 years, n=22) duration and 34 nondiabetic controls underwent diabetic neuropathy assessment: Neuropathy disability score (NDS), quantitative sensory testing (QST) including vibration pressure and thermal thresholds, nerve conduction studies (NCS), deep breathing heart rate variability (DB-HRV), corneal confocal microscopy (CCM) and intraepidermal nerve fibre density (IENFD) and AGEs, RAGE and GLO1-I expression in foot skin biopsies.


Patients with 40 years of diabetes demonstrated higher skin AGEs and RAGE and lower GLO-I expression. Patients with 40 years of diabetes who escaped diabetic neuropathy exhibited lower skin AGEs and RAGE and higher GLO-I expression in the epidermis, microvessels and basement membrane as compared to those with neuropathy and these expressions correlated with IENFD, CCM and NCS measures.


Patients with 40 years of diabetes and no diabetic neuropathy have decreased skin  AGEs and RAGE and increased GLO-I expression suggesting a potential role for these macromolecules as aetiological, marker of the disease as well as therapeutic target for diabetic neuropathy.